With Office 365 subscription plans you can create your best work with the premium versions of the Office applications across all your devices: Word, Excel, PowerPoint, Outlook, Publisher, Access (Publisher and Access are available on PC only) as well as access to additional OneNote features (features vary). You can install Office 365 across multiple devices, including PCs, Macs, Android™ tablets, Android phones, iPad®, and iPhone®. In addition, with Office 365 you get services like online storage with OneDrive, Skype minutes for home use, and advanced Outlook.com security. When you have an active Office 365 subscription, you always have the most up-to-date version of the Office applications.
Office 2019 is a one-time purchase with the classic versions of the Office applications such as Word, Excel, and PowerPoint for use on a single PC or Mac. The applications are not automatically updated; to get the latest version, you must purchase Office again when the new version becomes available. Current Office application versions available for one-time purchase are Office 2019 for Windows and Office 2019 for Mac. Previous versions include Office 2016, Office 2013, Office 2011 for Mac, Office 2010, Office 2007, Office 2008 for Mac, and Office 2004 for Mac. Office as a one-time purchase does not include any of the services included in Office 365. Learn more about the difference between Office 365 and Office 2019.